Postoperative Care. Posterior Stabilization Option. Intramedullary Tibial Option. Using the Tibial Spacer Option. All-Poly Tibial Option. Balancing the Soft Tissue. Ultracongruent and Traditional Posterior Stabilized Component Indications. MIS Natural-Knee® II. Surgical Technique.

Genome editing technologies provide the unprecedented ability to modify genetic material in a manner that is targeted, rapid, adaptable, and broadly accessible. Advances in genome editing form the foundation for new transformative applications across all of biology, ranging from highly personalized therapeutics to control of mosquito populations in the wild to reduce vector borne diseases. Extension of these technologies to gene drives and germline editing, which can alter the outcomes of inheritance, brings into focus the potential use of these tools in real clinical or ecological settings. While the potential for societal benefit from these technologies is immense, longer-term ramifications, such as the potential for these tools to impact large populations of organisms and ecosystems over many generations, must also be considered. Therefore, to support the safe and responsible use of gene editors, it is imperative that we innovate and build-in biosafety and biosecurity technologies early for future applications, including strategies to control, counter, and remediate the outcomes of gene editing.

Co-development of safety measures ensures the continued rapid pace of technological progress, helps realize the potential of gene editors, and, importantly, enables novel applications to be accessible to the broadest and most impactful possible range of communities for public benefit. Renee Wegrzyn is a Program Manager at DARPA working to apply the tools of synthetic biology to support biosecurity and outpace infectious disease. Wegrzyn holds Doctor of Philosophy and Bachelor of Science degrees in Applied Biology from the Georgia Institute of Technology. Penn International 50 Serial Number. • Upcoming Seminars • in 1 month • Previous Seminars • 02017 • • • • • • • • • • • • • 02016 • • • • • • • • • • • • • 02015 • • • • • • • • • • • • • • • 02014 • • • • • • • • • • • • • 02013 • • • • • • • • • • • • • 02012 • • • • • • • • • • • • • • • 02011 • • • • • • • • • • • • • • 02010 • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • 02009 • • • • • • • • • • • • • 02008 • • • • • • • • • • • • • • 02007 • • • • • • • • • • • • • 02006 • • • • • • • • • • • • 02005 • • • • • • • • • • • • • 02004 • • • • • • • • • • • • • 02003 • •. Will and Margaret Hearst • David and Abby Rumsey • Kim Polese • Shel Kaphan • Garrett Gruener • The Libra Foundation • Peter Baumann • Brian Eno • Greg Stikeleather • Richard and Angie Thieriot • Nion McEvoy • Cameo Wood • Susie Tompkins Buell Fund • Panta Rhea Foundation • Ping Fu • Peter Schwartz • The Gordon and Betty Moore Foundation • Dean Ornish • The Baum Foundation • Lawrence Wilkinson • The Long Now Membership We would also like to recognize George Cowan (01920 - 02012) for being the first to sponsor this series. Seminars About Long-term Thinking is made possible through the generous support of The Long Now Membership and our Seminar Sponsors. We offer $5,000 and $15,000 annual Sponsorships, both of which entitle the sponsor and a guest to reserved seating at all Long Now seminars and special events.

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